I took the CoQ10 in the powdered form. I just put it in a spoon, put in my mouth and drank some liquid. I think the instructions are to take it every day for the specified time period.
I'm guessing you would not know if they are in the cranium or not. I did that protocol just to be on the safe side but saw no results, including no die off. So I'm guessing the standard herbals and zappers had already killed them, for my problems anyway.