There is evidence suggesting that micronutrients -- vitamins and minerals found in food -- may affect fat loss or gain, Trembley said. For example, a study led by Trembley found that female subjects in a placebo group couldn't achieve significant weight loss, despite following a carefully restricted diet, while those who took a calcium supplement showed better weight loss results. It's possible that as with glucose, the brain can recognize low levels of micronutrients like calcium, Trembley said, and regulates appetite control in order to correct them.