Elevated cortisol and oestrogen: Thyroid resistance may also occur in the form of elevated cortisol. High, prolonged cycles of cortisol excretion due to stress directly stimulate reverse T3 production. High levels of oestrogen can also displace thyroid hormones off their receptors. When selenium is deficient, the production of T3 is inhibited and fat deposition as well as water retention creep up, due to the lack of fat burning T3. The whole metabolism slows down. Yes, stress can make you fat, tired and sluggish. A very effective way to escape from a stress loop like this is to meditate regularly. The relaxation and detachment lowers cortisol activity without drugs.
Factors that cause r T3 to dominate: Pregnancy, fasting, liver disease, renal disease, stress and cortisol.