DESSAU: Drug Interactions Of Ivermectin by ICU ..... Morgellons Disease Forum
Date: 1/15/2011 6:08:52 PM ( 7years ago)
Benzodiazepines: Ivermectin may potentiate the activity of benzodiazepines. Concurrent therapy with ivermectin & benzodiazepines is not recommended.
Inducers or Inhibitors of the p-Glycoprotein Transport System: Ivermectin appears to be a substrate of the p-glycoprotein transport system; thus, interactions with inhibitors (e.g., amiodarone, carvedilol, clarithromycin, cyclosporine, erythromycin, itraconazole, ketoconazole, quinidine, ritonavir, tamoxifen, & verapamil) or inducers (e.g., amprenavir, clotrimazole, phenothiazines, rifampin, ritonavir, & St. John’s wort) of the p-glycoprotein transporter are theoretically possible.
Alcohol: Concurrent administration of single doses of ivermectin (150 mcg/kg) & alcohol 4.5% v/v (400 mg/kg average dose) resulted in substantial increases in plasma ivermectin concentrations in healthy individuals, indicating a potential pharmacokinetic interaction. (IMHO, increasing the plasma concentration is a good thing. You get more drug in the blood to blast the bstrds, more bang for your meds $buck$, & a nice toddy for the body ~~ lol. That's why I take the vet med Agrimectin cattle pour-on suspension since it's alcohol-based & the tablets, paste, & other types of suspensions aren't.)
Anticoagulants: In one patient receiving acenocoumarol (not commercially available in the US), excessive hypocoagulability was reported after occupational contact with insecticide formulations of ivermectin (Epimek, not commercially available in the US) & metidation (Ultracid, not commercially available in the US). The manufacturer states that no additional case reports of an interaction between ivermectin & oral anticoagulants have been received to date.
(Extract from Medscape Ivermectin Drug Monograph: http://www.medscape.com/druginfo/monograph?cid=med&drugid=17846&drugn...)
Hope this info helps you in your parasite battles!
Cheers ~~ ICU
My Curezone Posts: http://curezone.com/forums/s.asp?f=762&c=0&ob=d&m=ICU
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