I have used two bottles now. My money is very tight right now, so when I ran out recently, I didn't order another one. well, the whites of my eyes began turning yellow again and I felt very sick. I ran out immediately and bought a solgar formula and it's been helping a good bit ( I have to take twice the recommended doseage, though). I learned about the livatone Plus from an email friend I met through Curezone. She has her liver tested regularly ( she is in the UK where she can get this for free ) and she says it brought down her elevated enzymes.