Something just occurred to me. Since glutamine is known for its ability to stop diahrrea, the glutamic acid in the mushroom extract might worsen constipation in some people. I suggest more water or herbal tea throughout the day if this happens.
I remembered because I found that Intestinew constipated me at a full scoop, but half a scoop was fine. Haven't taken it for a year. There's a good shot of glutamic acid in Odor Cleanse/Champex/Pro M. Glutamic acid converts to glutamine. I settled on 7 capsules of Odor Cleanse because 8 slowed my bowels down. You may need to adjust dose or increase water intake.