I took 1 capsule 2 nights in a row. It seemed to make my bowel spastic, I had diarhea 4 to 7 times during the day. I looked at the ingredients and noticed it had habanero pepper in it, so now I think it has to do with my blood type. I am blood type A and cannot handle hot peppers. About 40 per cent of the population in USA are type A is what I've read. So is there any product that uses ginger in it rather than cayenne and hot peppers that act as an irritant to me? That is the only hot spice I can think of that does blood type A's well. I normally have a very healthy diet, mostly macrobiotic. So I rarely have problems with constipation. I rarely ever had diarhea.