SAMe is VERY expensive, for most it isn't needed. My Dad took it for a while but the TMG seems to have diminished his need for SAMe so that is a far cheaper way to go also the TMG lowers Homocysteine levels which can irritated arteries and heart.
TMG is a good one if you already have B vitamin intake, they also have Homocysteine + which is pretty much TMG plus Bs: