Since we are all different I would think that we also react differently.
Way back I used them and even with the heat on it but I never noticed anything.
Some person had used them every night and her belly went away, so tried that too, but for me no such luck.
Then last year tried the Colon Cleanse and it made me sick. As you can tell I had not much luck.
Now it is different with liverflushing, it changed my life, but I understand not everybody is as lucky as me. Liverflushing got rid off my allergies, aches and pains in different part of the body. And including a healthier lifestyle dropped 6 prescription drugs.
I am believer in trying things, in this way you will find out if it works for you.