I have never used the Colonix before. However, I have been an avid Oxypowder for about 3 years. The benefits of the Oxypowder not only including cleansing the entire intestinal system over a period of time. However, since this product is an Oxygen based intestinal cleanser, the oxygen will be released into the blood system. This allow the oxygen to reach other parts of the body. The Oxypowder will also help the bowels muscles to re-train themselves. The Oxy-Powder will also increase your urgency to go to the restroom. The movements that you experience while taking the Oxy-Powder are very liquified, most people compare the movements to diarrhea. However, the liquid movements that you experience will Oxy-Powder there is no risk of electrolyte imbalance, since the Oxy-Powder is pulling water from the body.