I also have taken Modiflan for nickel and cadmium toxicity also. I used the Modiflan' 6 pills a day for 4 months. My ears that were constantly broke out bloody and crusty if I wore earrings were no longer a problem. I had this problem since I was a young girl and had my ears pierced. I could not wear earring for more than 1 or 2 hrs without horrible breakouts. Now I can where them and any jewelry all day long. Then about a year later I tested for heavy metals with a urine test. It showed high in cadmium. I took Modiflan again as I knew it had worked before for me. I took it 6 pills a day first thing in the morning on an empty stomach with a glass of water. Then 2 months later I took another urine test and I was showing clear. I agree, Modiflan is a keeper.