I also take a multi-mineral in the morning because I read Licorice depletes Potassium levels. Licorice Root seems to be the main thing improving my state. I'm taking a break now from it and Isocort does not seem to be doing the trick. However, I understand that it takes time (months) for Isocort to do its magic. I'm currently looking for a substitute for Licorice Root for when I need to take a break because of the side effects.