Good question. I have been taking hydrangea root in tincture form along with chanca piedra in tincture form for 4 weeks now in preparation for flush #6 tonite!! So, we shall see... I noticed at first that I'd get a good twinge in my liver/gallbladder area the first few days. Also, feel a bit drained (hmmmm "drained"...) most days since I started. The jury is still out for me but should know by the morn... I have high hopes!