No, I don't think taking it for so long is a problem. As long as I am getting "mud" out of my system and not eat the perfect diet of only fresh fruit I will continue to use it. I have cleaned up my diet tremendously over the past 12 months and I have seen amazing results. As MH has stated many times, cascara sagrada must be mixed with other herbs such as the herbs in LBB. For most of the 12 months I was taking 2 capsules with each meal. I recently cut down to 1 capsule per meal and I have equally spectacular results. I have found that cutting down to 1 works even better. I think 2 capsules works too good and probably compacts the bowel movement somewhat. MH has stated he has been taking LBB for 15 years and experienced no harm.