1. both ozone and peroxide impart extra oxygen to the body, so both are good. but peroxide is more reactive and you have to be more careful with it. you have to carefully regulate dosage levels, and you hvae to be sure to take on empty stomach etc. with ozone, once you get used to it you can do as much as you like. its much more user friendly so to speak. some don't like the taste of the peroxide, the ozone water tastes great to me. i have done both and MUCH prefer the ozone water to the peroxide. but it could also be a personal preference thing.
2. you may or may not have die off symptoms, it totally depends on the specific health issues you are dealing with. i drink one big glass per day first thing in the am on an empty stomach. you can drink as much as you like, but just be sure to do it on an empty stomach and then wait a while before eating. you can drink ozone water indefinitely, its great for your health, why stop?
3. ozone water has never interefered with any supplement i have taken and i don't know of any it would interfere with. tho it possible that some prescription med should not be mixed with ozone water, but not really sure about that. also DMSO and oxygen therapy should NEVER be used together. but things like enzymes or probiotics or herbal supplement will only be affected positively by the ozone water. MSM increases the body's ability to take up oxygen.
4. all those ways of gaining oxygen are wonderful, try them all. but there is something unique about ozone water that those don't do, thats been my experience anyway.