You purchase Ornithine at a health food store. It's kinda expensive (I thought) but worth it. I did not take it my 1st cleanse and that was when I probably needed it the most. I was awake most of that night. I then took at least 8 capsules when I did another flush. What it does is helps you sleep. It removes the toxins that will be released when the stones (which are bacteria-filled) begin moving out of your liver/gallbladder.