Yes, I have tried coffee enemas. That is how I first found out that I had parasites, because it started to pull them out. I had been doing Gerson Therapy at the time to try to get over my chronic fatigue. I used to get really bad migraines and that's what I would do to get relief from the pain. I believe migraines come from the liver, so I know for sure it helps detox the liver. I know coffee is good for that, although I am always careful to use organic. It may be too strong for me to actually drink, though. When I was drinking it a month or two ago I always made an extract by soaking the coffee grounds in cold water. That way it didn't give me heartburn. But it did seem to make me tired. I will have to think about it more before getting back into drinking it.