"The amino group in chitosan has a pKa value of ~6.5, thus, chitosan is positively charged and soluble in acidic to neutral solution with a charge density dependent on pH and the %DA-value. In other words, chitosan is bioadhesive and readily binds to negatively charged surfaces such as mucosal membranes."
So, if it can readily bond to mucosal surfaces (maybe using vinegar-acetic acid 5%-to partially solubilize) and it could, in fact, contribute to reduced hyperkeratinization, due to the inhibition of fibroblast proliferation, maybe it would help. I think I'm gonna run out and pick some up. I'll keep you guys posted.