check out natural latex mattresses. They're expensive, and I think need to be flipped routinely, but it's worth looking into. Supposed to be totally non-toxic. I guess foam off-gasses for quite awhile, I think some are worse than others. Not sure about Tempurpedic. Some people complain of getting really sweaty on those mattresses because they don't breathe. We have a knock-off tempurpedic with a wool/silk topper, and they started sagging like a month after we got them.