Can long-term guilt change brain chemistry?

I understand that she would have guilt. She has never been naturally prone to kindness (to say the least), but her hatred for her family intensified probably about two years after she (for no apparent reason) made this ENORMOUSLY big issue of abortion. I realize that, If I was a drug dealer or hardened criminal, she would not feel so uncomfortable around me, but I'm a Christian, and that probably burns her conscience (she DID say that she hates my guts and wishes that I were dead). I DO wish the situation could be better, but she has become Manic Depressive and has even come to think of illegal behavior as being exclusive to other people. I think that all her years of "embracing" hatred has actually changed her brain chemistry (she is and probably for a long time been a drug addict). I don't know whether to pray that she goes to jail as a menace to society or to pray for her health or what (yes, I have gone crazy). I don't know if there could possibly be a solution, but if the situation does ever get better, I want to understand how to be sensitive. Tweet