i just finished three intense months of high doses of primal defense. it is a very effective product. i assure you that whatever you are experiencing is die off and not the candida beating the probiotics. i was terribly ill for all three months i was on pd and have now gone down to three a day, while also having started threelac 2weeks ago. pd totally turned my health around (along with the body ecology diet), and i am so much better. i am hoping that taking threelac for the next few months will put me over the edge back to health. we'll see. hang in there with primal defense. my last month on it was the most difficult. and then the sickness passed and i have been feeling almost human again.