It is not only the damage to the immune system which prevails from over use of Antibiotics (mostly broad spectrum). In my opinion (and I am a true test subject...) I believe that broad spectrum (and maybe some regular) actually cause intestinal permeation.. At one point I had swollen lymphnodes throughout my body.. After a month this reddish blotch appeared on the white of my eye which I had to get surgery to take out. This blotch was a build of up waste... So this confirms that the Antibiotics did cause my intestines to permeate garbage through them.....