I began using grapefruit seed extract abiut this time last year and had unbelievable results for many months-but-unfortunately at that time did not know about rotating herbs and after about 6 months it completely stopped producing any effects! That was the closest I have come to getting well. Someone at a small herbal store I went into said this is common with GSE. ( Unfortunately they offered me no other replacements without a $50 dollar fee for the herbalists' time-isn't that a bunch of crap!) I cannot say enough about GSE-it is a great "broad spectrum" herb capable of killing many different things. You probably should rotate it with other things though to avoid my misfortune. *Also start off slow because it's strong and you WILL have bad die-off. { I am researching olive leaf extract currently and am also having good results with Capricin by Probiologic (caprylic acid). } Stannarad