Wow, mine is only a 120mg, and after a day, it works to well. Have you been checked for blockages~? My mother had polyps which cause her much problems, and after awhile a perforated colon. I only ask since it seems with a Vegan diet, regularity wouldn't be a problem.(Comes from someone uneducated in this subject, and I think mine is because I don't eat enough roughage.) Good luck to you.