Yes I have read Dr. Rubin's books and tried a very high dose of Primal Defense for 90 days ... it did not work for me. From reading the other forum messages, one possible reason for it not working could be that I have an layer of gunk protecting all the nasty bugs, parasites, worms, etc that Primal Defense is designed to attack. That assumes that I have gunk such as Mucoid Plaque lodged in my intestines - the existence of which the medical community denies entirely. If you have any other ideas I am all ears .... thanks!!