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Re: Very important question
 
dm0923 Views: 33,131
Published: 15 years ago
 
This is a reply to # 376,768

Re: Very important question


Hi all. I’ve only got a second (back on Sunday), but according to the biopsy report there were, in addition to other things, micro abscesses and a negative PAS. Additionally, some have reported (including myself) that we have some form of granulomas, slightly nodular swelling in our lips. According to http://pathhsw5m54.ucsf.edu/case29/image292.html from UCSF, “cultures and special stains for acid fast organisms and fungi should be done on all tissue that shows granulomatosis and/or microabscesses.”

According to: http://www.med.nyu.edu/dermatology/sem_conf/051606-7.html from NYU, “A negative periodic acid-Schiff stain on histopathologic examination makes cutaneous fungal infections, such as sporotrichosis or chromoblastomycosis, unlikely.”

So, with a negative PAS, micro-abscesses, and granulomas activity, it would be prudent to perform an acid-fast bacilli test. It might show nothing, but it would be informative and what if it did show something.

MOTT’s are rare; so is our condition.

Agreed, clofazimine is rarely prescribed and has some pretty negative side-effects. Such considerations make it all the more curious that a doc would prescribe it for our condition (I was wrong earlier: the drug also has some anti-inflammatory properties, but the mechanism is still unknown and much more effective anti-inflammatories exist; what would the motivation be for prescribing such a drug?).

Gotta run. Sorry for the hasty post (I’ll update after getting back).
 

 
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