Re: What about Dermovate (GlaxoSmithKline) (steroid ointment)?

Hi Alesiom11. I’ve been working on a list of various drugs/treatments tried by different people, in hopes of maybe finding correlations (which, due to the small number of cases, might not be statistically significant, but, at this point, I’m willing to fudge on the Science a little bit). Here’s a short summary of a person who used Dermovate; it worked while being used, but the symptoms came back after cessation of application. Here’s a further summary, mostly taken from: http://drugtalk.com/metronidazole/drugthread.php/t-122721.html

History and Symptoms:
There was a case of a 41 year old female who reported lip dryness/peeling/soreness, episodes of bleeding (she admitted to lip picking, but it didn’t say if the bleeding was a result of such activity; I assumed the bleeding was a result). She had no history of atopic dermatitis; had dry lips, with scaling/crusting, particularly involving the vermilion border; and was diagnosed with exfoliative cheilitis.

Examination:
Testing revealed a normal full blood count, slightly low serum ferritin levels, and a negative lip swab. Contact allergic cheilitis was excluded with negative patch tests, including: European standard series, facial and preservative series, oral series, perfumes and flavorings series, and personal toothpaste/moisturizer.

Treatment:
She tried the following treatments: hydrocortisone cream, fucidin cream (fusidic acid 2%, hydrocortisone acetate 1%), fucibet cream (fusidic acid 2%, betamethasone 0*1%), daktacort cream (hydrocortisone 1%, miconazole nitrate 2%), metrogel (metronidazole 0*75%), eumovate cream (clobetasone butyrate), blistex, soft white paraffin, iron supplementation failed.

She made a concerted effort not to pick/rub lips,

Dermovate ointment (clobetasol propionate 0*05%) was used sparingly twice daily for 3 weeks. This alleviated symptoms, but the cheilitis recurred upon stopping treatment.

Topical tacrolimus Protopic ointment(0*1%) was used twice daily. Cheilitis cleared within 4 weeks. Tacrolimus therapy was then reduced to once daily for a few additional weeks and then to alternate days. She now remains symptom free by using tacrolimus only when symptoms flare (she didn’t’ have any reported adverse effects from tacrolimus treatment).

Hope this helps

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