Curcimin comes from the spice Tumeric. I imagine there are several versions of Curcimin but I have never heard of cumanda.
More Info on Samento
Some of the beneficial properties of Samento are attributed to the pentacyclic oxindole alkaloids (POAs) that are found in the plant that act on the cellular immune system and demonstrate powerful immune system modulating properties. SAMENTO does not contain the tetracyclic oxindole alkaloids (TOAs) that are found in traditional Cat's Claw. TOAs disrupt central nervous system function and greatly inhibit the effects of the POAs.
Some researchers believe that Samento may be as much as 1000 times more effective than Cat’s Claw. One of the most important differences between Samento and Cat’s Claw is that Cat’s Claw is an immune system stimulant and Samento is an immune system modulator. Therefore, Samento can be used to treat all autoimmune disorders; this is not the case with Cat’s Claw.