Baycol - withdrawn from market
Cisapride - withdrawn from US market
dexfenfleuramine (redux, Fen-Phen) - withdrawn from market
Lariam (mefloquine) - Anti-malarial
Iressa - anti-lung cancer - withdrawn due to numerous deaths in Japan
Trovan - On August 30th the New York Times reported that thirty Nigerian families sued Pfizer in federal court August 29, saying the company conducted an unethical clinical trial of an antibiotic called Trovan on their children in 1996. Eleven children in the trial died, while others suffered brain damage, were partly paralyzed or became deaf.
Diflucan - (fluconazole) - oral yeast infection treatment
Arava - Yet another fluorinated drug called Leflunomide ("Arava") is being considered for market removal, and - once again - because of observed liver and cardiac toxicity. Please read the press release below, issued by the Public Citizen Group. Additional info follows the press release.
Crestor - Cholesterol lowering drug
Risperdal - Schizophrenia drug - The drug, Risperdal, has been commonly prescribed to Florida children in state care, including to a handful of boys who developed lactating breasts after taking it.
1)In 2000 Cisapride ("Propulsid") was withdrawn because it caused severe cardiac side effects
2) The drug Mibedrafil ("Posicor") was withdrawn after it was shown that patients with congestive heart failure showed a trend to higher mortality (1998).
3) Flosequinan was withdrawn in 1993 after it was shown that the beneficial effects on the symptoms of heart failure did not last beyond the first 3 months of therapy. After the first 3 months of therapy, patients on the drug had a higher rate of hospitalization than patients taking a placebo.
4) Astemizole (allergy drug) was withdrawn in 1999 because it also became associated with serious life threatening cardiac adverse events.
5) Fenfluramine and dexfenfluramine were withdrawn in 1997 due to serious cardiac adverse health effects.
(Other fluorinated drugs have also shown serious cardiac toxicity, such as Halofantrine, but remain on the market with only warnings issued so far.)
6) Tolrestat (anti-diabetic) was withdrawn in 1997 after the appearance of severe liver toxicity and deaths.
7) In 1992 Abbott withdrew Temafloxacin (anti-biotic) ("Omniflox"). The drug had caused deaths, liver dysfunction, etc.
8) Grepafloxacin was removed from the market in 1999 because of serious cardiac events.