I have only done two flushes. My Gallstones never showed up on ultrasound, but I've had gallbladder/liver pain nonetheless. I cleaned out 150 stones the first time, and felt significantly increased discomfort for the next 3 days. Then I improved quite a bit. It seems like I feel my best right before the cleanse. (Probably because I'm eating no fat!) I just did my second cleanse last week, and only got out about 40 stones (gravel sized) I never really have "attacks" where there's a noticeable start and finish to my discomfort. It's just an awareness of my gallbladder or liver, and a tight, pinching feeling under my ribs. Anyhow, after my second flush, I felt about the same for a couple of days. Not worse, and not better. But now I have had a couple more days of a flare-up. I can't help but think that I'm helping my health by doing these cleanses. I would just like to have a day or two with absolutely no sensation in my upper right abdomen. Since it always seems to be there in some degree or another, I sometimes wonder if stones are the real problem, or if something else is going on.