Milk thistle is an excellent herb, but alone isn't enough. You need to be supporting both phase one and phase two liver detoxification pathways. Milk thistle helps your liver rebuild new cells, not increase bile. Take a look at this site http://www.liverdoctor.com I've been taking her forumla for about a year and a half now. It's excellent. Prior to using it the whites of my eyes would turn yellowish. ( It does include milk thistle along with other herbs and B vitamins )