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Re: FLUKE DRUG PROTOCOL: Praziquantel & Albendazole

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yulia333 Views: 7,848
Published: 3 years ago
This is a reply to # 1,667,673

Re: FLUKE DRUG PROTOCOL: Praziquantel & Albendazole

This protocol needs to be updated. I used to cure intestinal flukes and some other trematodes. But praziquantel is useless in case of liver flukes.

"Although success has been seen in the treatment of F hepatica with dosages of 75 mg/kg tid for one day (23), there are many reports of post therapy relapse in both acute and chronic fascioliasis, even when dosages as high as 75 mg/kg/day are used for seven days (7,24Ė26). Such a treatment failure was observed in the present patient. Failure may relate to the resistive properties of the F hepatica tegument."

Some authors recommend Triclabendazole but I read that Fasciola hepatica can resist this drug as well. And finally Nitazoxanide was recommended as a drug of choice:

"Nitazoxanide efficacy against fascioliasis is worth mentioning, becoming an alternative to triclabendazole.
Moreover, its usefulness for the treatment of human cases not responding to triclabendazole [81] is of important additional value, given the spread of the resistance to this drug. However, it should be noted that a triclabendazole-resistant F. hepatica infected patient not responding to nitazoxanide treatment has recently been reported in the Netherlands [82]. In animals, triclabendazole resistance was first described in Australia [83], later in Ireland [84], [85], Scotland [86], the Netherlands [87], [88], and Spain [89]. Very recently it has also been found in southern Brazil [90] and Argentina [91]. Up to that moment, triclabendazole resistance only concerned livestock in animal endemic areas, but unfortunately it has very recently been also described in humans [92] in a human highly endemic area such as Cajamarca, Peru [6]."

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