I don't remember having any issues with milk thistle. I just took one capsule a day and two cranberry extract. I haven't taken it recently so idk if my body would react differently because of the whipples disease. I do know this bacteria targets all organs especially the liver and skin, I can clearly see the effects it's had on my skin which is the largest organ in the body. I probably should be taking it unfortunately I've been spending most of money on pine needle oil and black seed oil. If I was rich I would just purchase and take everything I need but sadly I'm not and been trying to get disability for 3 yrs now. I literally have no quality of life right now.