I'm not arguing for or against the "kidney cleanse" products. I did not use them.
I had a lead and cadmium problem, including bone density problem in my mid 40's and slightly low eGFR kidney numbers and the typically long list of mild to moderate symptoms that one would expect.
I used DMSA + ALA--Cutler's protocol. After 1.5 yrs of it and his recommended supplements during detox my bone density and eGFR improved into the 60s according to followup tests. After 3 yrs or so eGFR had improved into the 70s. After 5 yrs it continued to be in the 70s.
Lots of little symptoms improved or disappeared.
I used unusually low doses of the chelators because they made me somewhat more fatigued, fogged out and lethargic while on round and for a half day after.