1. "...tumor is likely a late-stage effect rather than the cause of the disease itself..."
2. "... one-dimensional thinking ..."
my comments (first on 2 then 1)
There is more then a tumor in cancer. It is an interaction between tumor and organism. Medical establishment does not want us to think so. With host resistance on our side smaller doses of drugs are required. The second dimension (host resistance) is missing in current thinking.
As regard to systemic disease, please visit the site or look in you tube for professor Zajicek. I'll make a short summary of the ideas there:
A carcinogen causes the depletion of stem cells. At the very beginning this is compensated by a minor tumor and patient despite some fatigue feels healthy. With time the deficiency may
grow and so does the tumor. Tumor is a new organ, fully controlled and fully
nourished by the organism. It is assumed that stem cells also secrete a vital substance to sustain tissue and prevent Cachexia. One may consider tumor as a factory to produce
the missing proteins due to stem cells loss. This factory, so to speak, is not as efficient as the original depleted stem cells and quality is traded for quantity.