I am not sure I fully understand your question but I will try to answer it. When I became extremely ill I could not take any supplements I was having reactions to them. My downward spiral was triggered by stress but understand stress comes in a multitude or forms:
Trauma physical or mental
A Bad Relationship
Basically anything that causes stress mental, physically and/or emotional. Overtimes we were down our bodies resources to deal with stress and our brain also becomes altered because of stress. I had two other friends that experienced the same thing. Both were in very stressful relationships and after a year of the stress from the relationship all of a sudden they were so sick they could not leave their homes.