Since you have done the Master-Cleanse before and want to do it again then I think you should go for it. Just my opinion but I would stay on my pills while doing so. Medications can be taken during the cleanse. I took my blood pressure meds & anti-depressant while cleansing and found no adverse affects. Hope this helps you. I'm starting again on the 3rd if you want to join in. I think there are 2 others that are starting at the same time so we can all keep in touch and Pepe will help you with any questions as he is a long-time cleanser as well as afew others on this forum. We will never be alone.