My estrogen and DHEA was normal but my progesterone was really low as we'll as testosterone. And I am 49. I know your body will steal from other hormones to make cortisol also if your thyroid and adrenals are working right the added hormones don't act as they should. I hear of a lot of people getting messed up on them but some they work wonders for. I was told I might need to add progesterone at some point in time but I still have not. I also know there are people that only do tiny amounts.