depends on the dose. don't abuse it. Supposedly if you can keep it to under 20mg for an average sized person you don't cause much long term damage.
Some people gain substantial weight around the middle on it, including a friend. She's done better on generous doses of pregnenolone, progesterone, some adrenal cortex glandular and other related supplements plus a small doses of HC. However, she seems to have more of a secondary AI/AF.