" Iodine deficiency is a big cause because it causes a loss of myelination of peripheral and central nervous system tissues. A lack of Iodine also means the person can not myelinate their nerves because they can not access the ketogenic pathway to myelinate nerves. This has two major effects on nerves. One it decreases the insulation of nerves and can cause a short circuit to develop. The second is more interesting and more significant. It would decrease the the DC current of nerve fibers that has been found experimentally to be tied to tissue regeneration in mammals.
Early humans found them selves in an environment loaded with iodine, DHA, and seawater. Today’s modern humans do not.
Sufficient dietary Iodine is crucial for proper ketogenesis in our nerves, liver and in our brain. Ketogenesis is critical for myelination of all nerves in humans. These are just three of many tissues that diabetics have massive trouble with. When iodine is low, estrogen levels tend to be higher in both sexes. This also is associated with elevated SHBG on testing.
Estrogen also blocks the absorption of iodine from the human gut. So any cause of leaky gut can also be an etiology for neuropathy even in a non diabetic. I see this many times a week when some one comes in with a normal MRI and classic radicular pain they think is from compression or from a disc. This is why women have higher rates of neuropathy, MS, and hypothyroidism than men. It is also why they have less myelin than men in adulthood naturally. Myelination is a proxy regeneration because of the loss of the regenerative DC current below the myelin level and outside the axon of nerve cells.
You might be shocked to learn that artificial blue light in your environment destroys iodine absorption due to poor melatonin signaling in the brain. When iodine is low in nerves over time it causes lower levels of vitamin D and vitamin K2 and atherosclerosis usually develops in the blood vessels that feed the vascular supply to nerves. You might be shocked to learn loss of melatonin signaling in the brain and in nerves also increases estrogen levels and, this in turn, further lowers iodine absorption from the gut in both sexes to cause peripheral neuropathy. This is the most common cause of peripheral neuropathy I see in my medical clinic.
As the disease progresses, blood flow to the nerves decreases because of the development of atherosclerosis from a chronic low vitamin D, vitamin K2 level and iodine. The patients also tend to be dehydrated and have higher BUN/creatine ratio’s as well. This limits the amount of oxygen and nutrients to the nerves cells. This damage occurs at the vasa nervora. Nerves are fundamentally different in how they transport glucose than other cells in the body.
Membranes of nerves have insulin independent glucose transport mechanisms. They rely on the polyol pathway. This pathway uses polyhydroxyl alcohols. This pathway is the one responsible for many eye diseases like macular degeneration and optic neuritis. These diseases all affect the ability of the eye to absorb electromagnetic signals from sunlight to send to the retina and pineal gland." http://jackkruse.com/what-is-peripheral-neuropathy/