Glad to hear it about the enemas! Many are skiddish but I see that you are ready for the full battle ahead!
My symptoms are mainly around a total inability to detox without getting severely ill and causing extreme fatigue. I've had my share of constipation and weight gain also. I was a very fit size 4 just 2 years ago, and now I'm a size 12. This all started after an amalgam was removed inproperly sending me back to the chronic fatigue syndrome I had thought I was cured of after following a high carb, low fat vegan (high raw) diet for several years. It had totally rejuvenated me and turned back the clock, I looked like 25 year old again, it was awesome!
I won't give up though, and am thinking of starting the liver flushing again. I don't do well with supplements also, need to test the MTHFR you mentioned. Not sure how to proceed with the supplementing of that but feel it could help.