I take Effexor, and the nausea is so bad that I can't go anywhere for 3 to 5 hours after taking it because I will just be dry heaving and running back and forth between the bathrooms. As a consequence, I only take it when I know I'll be home. Has anyone else had this problem? What did you do about it? I also have extreme numbness and as a result sex feels like nothing. I have been told this is basically unavoidable (I am already on the lowest dose). I like feeling hopeful and caring about life, so I keep taking the medication, but only about twice a week or when I feel myself really slipping. So far I haven't found any other medications that really work for me. Paxil was alright but caused weight gain, and it didn't work nearly as well as Effexor anyway. Anyone want to talk about meds?