"There have been a few reports in Japan of a rare condition called insulin autoimmune syndrome in people using alpha lipoic acid. The condition causes hypoglycemia and antibodies directed against the body's own insulin without previous insulin therapy."
Sounds like it's unusual. Rare, even. So it's not a normal "depletion".
Also, we have to be careful. There are two different ALAs. Alpha-linolenic acid and alpha-lipoic acid. They're both called ALA. Probably we should refer to them by their long names to avoid confusion.