I am little bit late to this party (thread). My experience:
jumped into cleansing, since I needed gallbladder surgery. Liver flushing, colon and kidney cleanse. Did not believe in parasite cleansing so skipped that. Liver Flushing got the liver flukes out. After 10 months went off 40 years of Dexedrine (diet pill)for energy and 3 anti-depressants(15 years). Liver flushed for 4 years.
Had boxes full of supplements after all the suggestions and one day dumped them all. There were not enough hours in the day to take them all.
Started again from scratch, tried several different diets.
I have tried a lot of different supplements and some helped and some I did not notice.
When I got to Iodine I had no detox because I already for a year I had done the vitamin C and brazil nuts and of course all the cleanses. I did high Iodine for 7 months and since then maintenance. I had one AHAH moment in that time like some light clicked on in my head, that was all. I take now 1-2 drops Lugol's 5% plus 5 drops iodide. Since we drink distilled water I put Concentrace mineral drops in it. One year I started TMG and realized later that I had a good summer, still use it.
Last year I was low on folate on my lab tests and my doctor told me to get L-Methylfolate, my MD knows I don't want drugs. Folate helps with depression.
I always take magnesium and potassium because I otherwise get leg cramps.
I still have a bunch of supplements and use them when needed for my gallbladder and/or my spinal stenosis.
So give yourself time, it is never too late, we are all different and Depression comes in different forms, mine they called A-typical.