Yes, you can take the first dose at night :D We did on our second round! We have done two cleanses, and no problems here. I was VERY sick before the first cleanse. Similar to what you are experiencing. I still have lots of Candida...and am gearing up to do a candida cleanse.
I would imagine that ANY question you have you could ask Humaworm and they would answer you! Our first cleanse we exchanged almost 50 e-mails between the two of us! They are VERY helpful and informed!
We did get really sick the first time we did it, but felt a lot better after, and even better after the second one and plan to do a third here in the next three months!!
If you choose to go ahead with the cleanse, there are a LOT of people who are here to support, help answer questions who have been there, cheer you on, and share where we have come from where we have been!!! Best of luck to you!!