I've got it and left it unopened until i'm ready to use the stuff. As far as the nystatin I feel the stuff working day by day. I can breathe a little better, by body dont ache as much, better concentration. I still have my ups and downs but i feel like i'm moving in the right direction. I did a bowel movement today and i saw like a white ball attached to my stool. not sure if its candida or not.