Also the original research here:
"Following orthoiodosupplementation, serum T4 and TSH levels usually go down and free T3 stays steady. I have seen TSH sometimes go up rather than down while T4 and free T3 did not change or may have gone up some. This does not mean that the patient was developing hypothyroidism but that the brain was stimulating the body to make more sodium Iodide symporters (NIS)…. While taking iodide, one may see an elevated TSH but we have to recognize that this is not a bad thing. TSH has many actions outside the thyroid that have been discovered…. Often a check of the patient’s T4, free T3 and TSH shows the T4 to go down, free T3 going down and TSH going up. Iodide is an essential nutrient that is absorbed by all cell lines. Its highest concentration is seen in the thyroid." http://iodineresearch.com/orthoflechas.html
"I'm not sure what to do. Hate to stop the Iodine without knowing what is happening."
All of the Iodine doctors say that 50mg a day is the recommended dosage, and that 100mg a day is only recommended in cases of deficiency disease such as FBD, PCOS, I have never seen an Iodine doctor recommend 250-300mg a day of iodine. IMO, try reducing your iodine intake to the doctor recommended 50mg a day to see what happens. Why are you taking such high dosages of iodine. Are you addressing a disease of some kind?