If you have the MTHFR mutation the B12 injections with hydroco are probably not a huge help. You would need methylcobalamin instead.
For about 15 months I've done a combination of approaches to detox copper. I did "Nutritional Balancing" hair analysis testing (well except for the fact that I didn't take the recommended copper supplements and the calcium they recommended was way too much for me).
I also followed the advice from the book by Ann Louise Gittleman about detoxing copper. And most recently I started doing three days on ALA (Cutler protocol - every three hours) and then a week off.
I can't even tell you how much better I feel - even though I'm not a 100%... I don't feel like I'm dying anymore (which is AWESOME)!