"Physiological cortisol supplementation accompanied by DHEA, by definition, does not produce any negative effects."
^That is a huge red flag statement to me. One thing that seems clear to me is that, besides needing food, our bodies are pretty much closed systems. Just listen to these commercials on t.v. with the never ending list of side effects for the latest drug on the market. Anytime I see claims that because our bodies produce something naturally like cortisol, that taking a synthetic cortisol replacement is the same thing and will have no negative effects, it's laughable and just unfortunate.