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Re: Immune restoration Th1/Th2 balance.
 

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ericbakker Views: 6,508
Published: 6 years ago
 
This is a reply to # 2,067,548

Re: Immune restoration Th1/Th2 balance.


Jorge, respectfully,

Hg is but a tiny piece of the immune-suppression puzzle, many other toxins are naturally involved, but further more, one must never overlook the significance of stress, cortisol regulation (or more importantly - dysregulation, and the HPA axis in terms of candida yeast infections.

In my clinical experience, possibly the most overlooked fact is the increased secretion of cortisol in the alarm phase of stress, and the hypo-secretion of glucocorticoids in the exhaustion phase. These inbuilt HPA regulatory mechanisms are absolutely central (yet generally entirely overlooked) to the regulation of the balance of Th1 to Th2 cytokines within sites of inflammation, and to the appropriate or inappropriate termination of the inflammatory response in any infections or autoimmunity.

One must therefore be always mindful of the effect of stress and cortisol regulation on both the humoral and cell-mediated response. To look at Hg (or any toxins for that matter) without first elaborating on the significance of stress and candida is relatively short-sided in the treatment and ultimate elimination of candida. I will not argue with the point that folks need detoxification, I am ALL for the appropriate detox, but FIRST the lifestyle must be conducive towards the correct regulation of cortisol.

Thanks for the fantastic link, but this research is not really looking at the adrenal/hypothalmic/pituitary role in immunity, it has a strong focus on factors which increase the TH2 response. It would have been more balanced if it also mentioned critical factors which assist in the regulation of the polarization of newly activated naive T cells into mature Th1 or Th2 cells. And cortisol is one of them, and to me it makes more sense to initially ensure that a person's stress axis is functioning optimally, and if with correct lifestyle (including dietary) recommendations there is little to no amelioration in their poor immune response, we go looking further afield.

Perhaps the most important hormones regulating type 1 and type 2 outcomes are the catecholamines (adrenalin and noradrenalin - stress hormones). It has been known for 30 years that lymphocytes express catecholamine receptors. Catecholamines inhibit type 1 cytokine production and stimulate the transcription and secretion of type 2 cytokines from a variety of leukocytes.

Stress = immune suppression. Fix the person's ability to regulate stress in their lives and you have just allowed them kick a chronic yeast infection in the pants.

Here's a good one for you:

http://cid.oxfordjournals.org/content/32/1/76.full





 

 
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